Paradoxical association between blood modular interferon signatures and quality of life in patients with systemic lupus erythematosus.

Objectives: Blood transcriptomic IFN signature is a hallmark of SLE. The impaired health-related quality of life (HRQOL) observed in SLE is poorly related to disease activity. The aim of this study was to test how IFN signatures were associated with HRQOL in SLE patients.