Publications by authors named "Elisabeth Seidel"
The naturally occurring dipeptide carnosine (β-alanyl--histidine) specifically attenuates tumor growth. Here, we ask whether other small imidazole-containing compounds also affect the viability of tumor cells without affecting non-malignant cells and whether the formation of histamine is involved. Patient-derived fibroblasts and glioblastoma cells were treated with carnosine, -alanyl--histidine (LA-LH), β-alanyl--alanine, -histidine, histamine, imidazole, β-alanine, and -alanine.
View Article and Find Full Text PDFBackground/aim: Pancreatic ductal adenocarcinoma (PDAC) and extrahepatic cholangio-carcinoma (eCC) represent two cancer entities with devastating prognoses. Despite recent progress in research and treatment, therapy remains challenging. Cancer stem cells (CSCs) have been shown to play an important role in metastasis and chemoresistance.
View Article and Find Full Text PDFTumor-stromal cross-talk modulating the therapeutic response in pancreatic cancer.
Hepatobiliary Pancreat Dis Int
October 2018
Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant solid tumor with a dismal prognosis. The stroma component makes up to 90% of the tumor mass and is thought to be one of the main reasons for the tumor's high chemoresistance. Cancer associated fibroblasts (CAFs) have previously been identified to be the key stromal players.
View Article and Find Full Text PDFArticle Synopsis
- A study was conducted to assess a tailored treatment strategy for patients with HIV-related Hodgkin lymphoma (HIV-HL) since standard therapies remain unclear despite improved outcomes due to antiretroviral therapy.
- *Patients with different stages of HIV-HL were treated with various chemotherapy regimens, including ABVD and BEACOPP, along with radiation therapy for some groups, leading to high complete remission rates across stages.
- *The findings showed a 2-year overall survival rate of 90.7% and suggested that the treatment effectiveness in HIV-HL patients can be comparable to that of HIV-negative patients with the same type of lymphoma.*
Background And Purpose: A commonplace explanation for postprandial fatigue is the assumption of the redistribution of perfusion from the cerebral to the mesenterial territory. However, this assumption has never been scientifically proven.
Methods: Because approximately 70% of the blood flow in the common carotid artery (CCA) is directed to the internal carotid artery, this vessel can be seen as a major brain-supplying artery.