Publications by authors named "Elisabeth M G de Vries"
Article Synopsis
- The study focuses on primary sclerosing cholangitis (PSC), a serious liver disease with unclear genetic causes, aiming to understand the genetic factors that influence its progression and complications.
- Researchers analyzed data from 3,402 PSC patients, examining over 130,000 genetic variants to find associations with disease outcomes using statistical models.
- They discovered a specific genetic variant (rs853974) linked to liver transplant-free survival, showing that individuals with certain genetic profiles have significantly different survival rates post-diagnosis.
Background & Aims: Biomarkers reflecting disease activity and prognosis in primary sclerosing cholangitis (PSC) have not been firmly established. Enhanced liver fibrosis (ELF) test was previously reported to predict outcome in PSC. We aimed to validate the prognostic utility of ELF test in an independent, multi-centre, retrospective PSC study population.
View Article and Find Full Text PDFUnlabelled: Histologic scoring systems specific for primary sclerosing cholangitis (PSC) are not validated. We recently determined the applicability and prognostic value of three histological scoring systems in a single PSC cohort. The aim of this study was to validate their prognostic use and reproducibility across a multicenter PSC cohort.
View Article and Find Full Text PDFBackground: Primary sclerosing cholangitis (PSC) is a slowly progressive liver disease. Reliable biomarkers to predict outcome are urgently needed to serve as surrogate endpoints and/or stratifiers in clinical trials. Reduction in serum alkaline phosphatase (ALP) has been proposed as prognostic surrogate marker in PSC.
View Article and Find Full Text PDFBackground & Aims: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease. At present, there is no appropriate histologic scoring system available for PSC, evaluating both degree of necroinflammatory activity (grade) and fibrosis (stage). The aim of this study was to assess if three scoring systems, commonly used in different liver diseases could be applied for grading and/or staging of PSC.
View Article and Find Full Text PDFBackground & Aims: Primary sclerosing cholangitis (PSC) is a progressive cholestatic liver disease of unknown cause, but strongly associated with inflammatory bowel disease (IBD). Potential risk factors triggering PSC have never been studied on a population level. The aim of this study was to evaluate smoking, appendectomy, family history and geographical distribution in a population-based cohort of PSC patients, as compared to IBD control patients and healthy controls (HC).
View Article and Find Full Text PDFBiomarkers for disease progression of primary sclerosing cholangitis.
Curr Opin Gastroenterol
May 2015
Purpose Of Review: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown origin. There is no medical treatment of proven benefit on survival; once patients have progressed to end-stage liver disease, the only treatment option is liver transplantation.
Recent Findings: Over the last years, some progress has been made in identifying biomarkers of PSC disease progression.