Publications by authors named "Elisabeth Le Prise"
Purpose: The ongoing phase 2/3 PRODIGE 26/CONCORDE trial compares chemoradiation therapy with and without dose escalation in patients with locally advanced or unresectable esophageal cancer. The results of a benchmark case procedure are reported here to evaluate the protocol compliance of participating centers as part of quality assurance for radiation therapy.
Methods And Materials: Volume delineation, target coverage, and dose constraints to the organs at risk (OARs) were assessed on treatment plans of a common benchmark case performed by each participating center.
Pediatric Localized Intracranial Ependymomas: A Multicenter Analysis of the Société Française de lutte contre les Cancers de l'Enfant (SFCE) from 2000 to 2013.
Int J Radiat Oncol Biol Phys
September 2018
Purpose: The objective of this study was to analyze survival and prognostic factors for children, adolescents, and young adults treated with postoperative radiation therapy (RT) for intracranial ependymoma.
Methods And Materials: Between 2000 and 2013, 202 patients aged ≤25 years were treated in the 13 main French pediatric RT reference centers. Their medical records were reviewed for information, treatments received, and survival rates.
Article Synopsis
- - Ependymoma is the third most common brain tumor in children, and radiation therapy is commonly used after surgical resection, with imaging playing a crucial role in treatment outcomes.
- - A national study reviewed data from 121 patients to assess the impact of preoperative and postoperative imaging on survival rates, focusing on tumor volumes and abnormalities detected in FLAIR images.
- - Findings revealed that patients with postoperative FLAIR hyperintensities had significantly lower disease-free and overall survival rates, indicating that these imaging markers may indicate residual disease and assist in managing patient treatment.
Purpose: To investigate the patterns of failure after radiotherapy for pediatric intracranial ependymoma and their correlation with dose parameters.
Methods: Between 2000 and 2013, 206 patients were treated in France. MRI scans at relapse were registered to the original planning CTs for topographic analysis of failure patterns.
Article Synopsis
- - The study aimed to analyze the long-term outcomes of two radiation therapy approaches for prostate cancer patients, focusing on event-free survival (EFS) and overall survival (OS), while also considering the impact of hormonal therapy and pelvic node irradiation.
- - Conducted between 1998 and 2004, the study involved 446 prostate cancer patients, comparing outcomes from pelvic nodes plus prostate radiation versus prostate-only radiation, with an emphasis on determining risks through patient stratification.
- - Results showed no significant differences in OS or EFS overall, but a post hoc analysis revealed potential benefits of pelvic irradiation in low-risk patients not receiving hormonal therapy, especially when lymph node involvement risk was low.
Objective: The aim of this study was to evaluate the potential of simultaneously modulated accelerated radiation therapy (SMART) to reduce the incidence of severe acute oesophagitis in the treatment of unresectable locally advanced non-small-cell lung cancer (LANSCLC).
Methods: 21 patients were treated with SMART and concomitant platinum-based chemotherapy. The prescribed doses were limited to 54 Gy at 1.
Background: The performance of randomized controlled trials (RCTs) is often hindered by recruitment difficulties. This study aims to explore the pre-screening phase of four prostate cancer RCTs to identify the impact of a systematic pre-selection of eligible patients for RCT recruitment.
Methods: The pre-screening of four RCTs opened at the Comprehensive Cancer Center in Rennes was analyzed retrospectively (French Genitourinary Tumor Group (GETUG) 14, 15, 16, and 17).
Objective: To analyze late urinary toxicity after prostate cancer radiotherapy (RT): symptom description and identification of patient characteristics or treatment parameters allowing for the generation of nomograms.
Methods: Nine hundred and sixty-five patients underwent RT in seventeen French centers for localized prostate cancer. Median total dose was 70 Gy (range, 65-80 Gy), using different fractionations (2 or 2.
Background: The objective was to analyze locoregional (LR) failure patterns in patients with head-and-neck cancer (HNC) treated using intensity-modulated radiotherapy (IMRT) with whole salivary gland-sparing: parotid (PG), submandibular (SMG), and accessory salivary glands represented by the oral cavity (OC).
Methods: Seventy consecutive patients with Stage I-II (23%) or III/IV (77%) HNC treated by definitive IMRT were included. For all LR failure patients, the FDG-PET and CT scans documenting recurrence were rigidly registered to the initial treatment planning CT.
Purpose: This cost analysis aimed to quantify the cost of IGRT in relation to IGRT frequency and modality with Cone Beam Computed Tomography (CBCT) or orthogonal electronic portal imaging with fiducial markers (EPI-FM).
Material And Methods: Patients undergoing IGRT for localized prostate cancer were randomized into two prostate control frequencies (daily or weekly). Costs were calculated based on the micro-costing results according to hospitals' perspectives (in Euros, 2009) and the time horizon was radiation therapy.
Purpose: To perform a randomized trial comparing 70 and 80 Gy radiotherapy for prostate cancer.
Patients And Methods: A total of 306 patients with localized prostate cancer were randomized. No androgen deprivation was allowed.
Objectives. Esophageal carcinoma and cirrhosis have the overlapping etiologic factors. Methods.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to evaluate the benefits, toxicity, and quality-of-life outcomes of irradiating pelvic nodes in patients with nonmetastatic prostate cancer.
- A total of 444 patients were randomly assigned to receive either pelvic and prostate radiotherapy or just prostate radiotherapy, with various dosages and hormonal treatments allowed based on risk levels.
- After more than three years of follow-up, results showed no significant improvement in progression-free survival or quality of life with pelvic irradiation, although it was generally well tolerated.
Background: Radiotherapy (RT) after breast-conserving surgery (BCS) has produced significant reductions in ipsilateral breast carcinoma (BC) recurrence. It was shown previously that a delay in the initiation of RT resulted in a higher local recurrence (LR) rate. In the current retrospective analysis, the authors investigated whether the RT-adjuvant therapy sequence modified local-disease-free survival (L-DFS) after BCS in patients with early-stage, lymph node-positive BC.
View Article and Find Full Text PDFA 45-year-old man presented with a tonsillar tumor and rectal syndrome. Histology specimens revealed signet-cell adenocarcinoma of both the tonsils and rectum. The clinical course was rapidly degenerated with multiple metastases in the skin and bones.
View Article and Find Full Text PDFPurpose: To describe treatments and acute tolerance in a randomized trial comparing 70 Gy and 80 Gy to the prostate in patients with localized prostate cancer.
Methods And Materials: Between September 1999 and February 2002, 306 patients were randomized to receive 70 Gy (153 patients) or 80 Gy (153 patients) in 17 institutions. Patients exhibited intermediate-prognosis tumors.
We report two cases illustrating how Gm-CSF can facilitate rapid and persistent healing of ulcers associated with contact radiation therapy. This simple and safe method should be proposed for the treatment of chronic ulcers that develop in a formerly radiated zone.
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