Comparison of pharmacokinetic profiles of brand-name and generic formulations of citalopram and venlafaxine: a crossover study.

Background: Generic drugs are lower-cost versions of patent-expired brand-name medications. Bioequivalence is decreed when the 90% confidence intervals for the ratios of the generic to the reference compound for the area under the curve and maximum plasma concentration (C(max)) fall within a 0.80 to 1.

Haloperidol and risperidone have specific effects on altered pain sensitivity in the ketamine model of schizophrenia.

Rationale: The ketamine (ket) model reflects features of schizophrenia as well as secondary symptoms such as altered pain sensitivity.

Objectives: In the present study, we investigated the effect of subchronic oral treatment with haloperidol (hal, 0.075 mg/kg) and risperidone (ris, 0.