Publications by authors named "Elisabeth Hjardem Taudorf"
Article Synopsis
- - Acne fulminans (AF) is a serious and rare skin condition that can cause significant scarring, and standard treatments are often insufficient, leading to a need for better therapies.
- - A study reviewed 3 clinical cases and 12 cases from the literature where TNF-α inhibitors, particularly adalimumab, were used to treat AF, showing clinical improvement in a majority of patients after 1 to 7 months.
- - While the treatment showed promising results with mild and reversible side effects, more research, including randomized controlled trials, is necessary to determine effective dosages and timing for TNF-α inhibitors in AF management.
This review finds that topical corticosteroids and systemic corticosteroids are the mainstays of initial treatment for bullous pemphigoid and pemphigus diseases. Additional immunomodulatory therapies such as methotrexate, azathioprine and mycophenolatmofetil should be added early during treatment to minimize the adverse effects of chronic corticosteroid therapy and to augment improvement in the disease. Rituximab is a first-line immunomodulatory treatment for moderate to severe pemphigus disease.
View Article and Find Full Text PDFAblative fractional lasers (AFXL) are increasingly used to treat dermatological disorders and to facilitate laser-assisted topical drug delivery. In this thesis, laser-tissue interactions generated by stacked pulses with a miniaturized low-power 2,940 nm AFXL were characterized (study I). Knowledge of the correlation between laser parameters and tissue effects was used to deliver methotrexate (MTX) topically through microscopic ablation zones (MAZs) of precise dimensions.
View Article and Find Full Text PDFArticle Synopsis
- * The study found that MTX penetrated deeply into the skin within 15 minutes, achieving significant concentrations in the mid-dermis compared to untreated skin, indicating effective delivery.
- * Results suggest that AFXL can enhance MTX absorption without significant escape into the bloodstream, making it a potential alternative treatment for localized skin conditions.