Effects of dopamine on retinal and choroidal blood flow parameters in humans.

Aim: To investigate the effect of dopamine on retinal and choroidal blood flow in humans.

Methods: We investigated the effect of two doses of intravenous dopamine (5 and 10 microg/kg/min) via a randomised double-masked crossover study in 12 healthy subjects chosen from a total of 16. Blood flow parameters in retina, optic nerve head and choroid were assessed with bi-directional laser Doppler velocimetry, laser Doppler flowmetry and laser interferometric measurement of fundus pulsation amplitude, respectively.

Effects of adrenomedullin on ocular hemodynamic parameters in the choroid and the ophthalmic artery.

Purpose: Adrenomedullin acts as a vasodilator and may play a role in inflammatory processes in the eye. This study was designed to determine whether nitric oxide formation is involved in the response to adrenomedullin in the ocular vasculature in vivo.

Methods: The effects of systemic intravenous adrenomedullin (3.

Effects of dopamine on human retinal vessel diameter and its modulation during flicker stimulation.

We performed a randomized, subject-blinded, placebo and time-controlled, two-way crossover study in 12 healthy male subjects. Placebo or dopamine was administered on two separate study days. After saline infusion, dopamine hydrochloride was infused in three consecutive doses (5, 10, and 15 microg x kg(-1) x min(-1)).