Publications by authors named "Elisabeth Buvarp"
Nucleic Acids Res
October 2024
Article Synopsis
- Alzheimer's disease (AD) is a severe neurodegenerative disorder characterized by the buildup of amyloid plaques and tau tangles, leading to memory loss and brain damage.
- Researchers used a C. elegans model to explore the role of DNA glycosylases in AD progression, discovering that certain genetic modifications improved mitochondrial health, lifespan, and cognitive function in nematodes with tau pathology.
- The study highlights the importance of the DNA glycosylase NTH-1, showing it has additional functions beyond its enzyme activity, suggesting it could be a potential target for therapeutic strategies against tau-related diseases.
