Publications by authors named "Elisabet Costa"

Article Synopsis
  • * Key predictors for subclinical atherosclerosis included male sex, diabetic nephropathy, high HbA1c levels, older age, long diabetes duration, and tobacco use.
  • * The presence of subclinical atherosclerosis significantly increased the risk of major cardiovascular events and overall mortality, indicating a need for improved cardiovascular risk management in these patients.
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Objectives: To assess the clinical characteristics of patients with Charcot neuroarthropathy (CN) in Spain and to identify predictors for CN-related complications.

Patients And Methods: A retrospective study was conducted at five tertiary hospitals with diabetic foot care units in Spain. Data were collected from 83 patients, including demographic profiles, foot factors, diabetes characteristics, and presence of microvascular and macrovascular comorbidity, and a podiatric examination was also performed.

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SAP18, a highly evolutionarily conserved protein, has been proposed to be involved in multiple cellular processes, from gene regulation to mRNA processing. To gain further insight into the role of SAP18, we performed genome-wide expression profiling of dsap18 mutant Drosophila melanogaster embryos and we found that dSAP18 is required for the expression of immune and stress related genes. We show that dSAP18 colocalizes with histone H3 phosphorylation, which has been implicated in the regulation of genes in response to signaling stimuli.

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SAP18 is a highly conserved protein that was proposed to be involved in multiple cellular processes from autophagy to gene regulation and mRNA processing. In this paper we show that, in Drosophila, dSAP18 is a predominantly nuclear protein that associates to both chromosomes and the nuclear matrix. dSAP18 becomes nuclear early during development, at the onset of cellularization, and remains so all through embryo development.

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