Publications by authors named "Elisa Pierella"
Article Synopsis
- - Idro et al. conducted a study on the potential effects of doxycycline, an antibiotic, in treating onchocerciasis-associated epilepsy (OAE), specifically focusing on nodding syndrome (NS).
- - The research is groundbreaking as it is the first to examine doxycycline’s direct impact on this severe form of OAE.
- - Findings from the study indicate significant results that could influence future treatment approaches for those suffering from NS.
Context: The assessment of zinc status is difficult but essential for the identification of zinc deficiency and evaluation of interventions to improve zinc status.
Objective: The purpose of this systematic review (SR) and meta-analysis was to update the previously published SR of biomarkers of zinc status, conducted by the European Micronutrient Recommendations Aligned (EURRECA) network in 2009, to answer the question: Which putative measures (biomarkers) of zinc status appropriately reflect a change in zinc intake of at least 2 weeks?
Data Sources: A structured search strategy was used to identify articles published between January 2007 and September 2022 from MEDLINE (Ovid), Embase (Ovid), Cochrane Database of Systematic Reviews, and Cochrane Central Register of Controlled Trials (CENTRAL). Relevant articles were identified using previously defined eligibility criteria.
The bidirectional interaction between the gut microbiota (GM) and the Central Nervous System, the so-called gut microbiota brain axis (GMBA), deeply affects brain function and has an important impact on the development of neurodegenerative diseases. In Parkinson's disease (PD), gastrointestinal symptoms often precede the onset of motor and non-motor manifestations, and alterations in the GM composition accompany disease pathogenesis. Several studies have been conducted to unravel the role of dysbiosis and intestinal permeability in PD onset and progression, but the therapeutic and diagnostic applications of GM modifying approaches remain to be fully elucidated.
View Article and Find Full Text PDFArticle Synopsis
- * Oxidative stress results from an imbalance between harmful pro-oxidants and beneficial antioxidants, and is a key driver of cellular senescence.
- * The text reviews different types of antioxidants, including vitamins and flavonoids, that could potentially combat oxidative stress and help delay aging, highlighting a need for further comprehensive research in this area.
Alzheimer's Disease (AD) is a progressive neurodegenerative disease characterized by amyloid-β (Aβ) plaque deposition and neurofibrillary tangle accumulation in the brain. Although several studies have been conducted to unravel the complex and interconnected pathophysiology of AD, clinical trial failure rates have been high, and no disease-modifying therapies are presently available. Fluid biomarker discovery for AD is a rapidly expanding field of research aimed at anticipating disease diagnosis and following disease progression over time.
View Article and Find Full Text PDFArticle Synopsis
- Gut microbiota plays a crucial role in regulating various diseases, including those affecting the gastrointestinal tract as well as neurological conditions like Alzheimer's Disease (AD).
- Dysregulation of gut microbiota, known as dysbiosis, is linked to neurodegeneration and may offer new pathways for diagnostics and therapies.
- The review discusses potential strategies such as prebiotics, probiotics, and diet adjustments that could help restore gut microbiota balance and possibly improve AD diagnosis and treatment.
Dietary lipids have a major role in nutrition, not only for their fuel value, but also as essential and bioactive nutrients. This narrative review aims to describe the current evidence on nutrigenomic effects of dietary lipids. Firstly, the different chemical and biological properties of fatty acids contained both in plant- and animal-based food are illustrated.
View Article and Find Full Text PDFBackground: Soil-transmitted helminthiases are important neglected tropical diseases that result in a notably high number of disability-adjusted life years worldwide. Characterizing the interactions between the human intestinal microbiome and helminths is of interest in the development of alternative treatments that do not rely on chemotherapeutics and do not lead to drug resistance.
Methods: We recruited and obtained fecal samples from 32 pairs of mothers and children on Pemba Island and monitored their intestinal microbiota using 16S rRNA gene sequencing.