Publications by authors named "Elisa Mombelli"
Article Synopsis
- * The trial involves two groups: one receiving a 12-week supervised PA program and another receiving psychoeducation on PA and health, with assessments conducted at various stages to measure effectiveness.
- * It is hypothesized that the PA program will significantly reduce BPD symptoms and improve overall physical and psychological health compared to the control group, potentially leading to broader use of PA in BPD treatment.
Article Synopsis
- Stress can lead to mental health issues like depression, but not everyone reacts the same way; some people handle stress better than others.
- Scientists studied rats to understand why some rats became stressed and vulnerable, while others stayed resilient and healthy.
- They found that vulnerable rats had more inflammation in their bodies and problems with making proteins, while resilient rats had better communication in their brains, pointing to potential new ways to help prevent or treat stress-related problems.
Article Synopsis
- Alzheimer's disease affects memory and brain health and researchers are studying how the bacteria in our gut may play a role in it.
- A study was done where scientists gave special bacteria from Alzheimer's patients to healthy young rats to see if it would affect their behavior and memory.
- The results showed that the rats had memory problems that matched what was seen in the patients, suggesting that the gut bacteria can influence symptoms of Alzheimer's disease.
Background: Increasing evidence links the gut microbiota (GM) to Alzheimer's disease (AD) but the mechanisms through which gut bacteria influence the brain are still unclear. This study tests the hypothesis that GM and mediators of the microbiota-gut-brain axis (MGBA) are associated with the amyloid cascade in sporadic AD.
Methods: We included 34 patients with cognitive impairment due to AD (CI-AD), 37 patients with cognitive impairment not due to AD (CI-NAD), and 13 cognitively unimpaired persons (CU).
Background: Bipolar Disorder (BD) is a complex mental disease characterized by recurrent episodes of mania and depression. Lithium (Li) represents the mainstay of BD pharmacotherapy, despite the narrow therapeutic index and the high variability in treatment response. However, although several studies have been conducted, the molecular mechanisms underlying Li therapeutic effects remain unclear.
View Article and Find Full Text PDFMajor depressive disorder (MDD) is a complex mental disorder where the neurochemical, neuroendocrine, immune, and metabolic systems are impaired. The microbiota-gut-brain axis is a bidirectional network where the central and enteric nervous systems are linked through the same endocrine, immune, neural, and metabolic routes dysregulated in MDD. Thus, gut-brain axis abnormalities in MDD patients may, at least in part, account for the symptomatic features associated with MDD.
View Article and Find Full Text PDFBackground: Metagenomic data support an association between certain bacterial strains and Alzheimer's disease (AD), but their functional dynamics remain elusive.
Objective: To investigate the association between amyloid pathology, bacterial products such as lipopolysaccharide (LPS) and short chain fatty acids (SCFAs: acetate, valerate, butyrate), inflammatory mediators, and markers of endothelial dysfunction in AD.
Methods: Eighty-nine older persons with cognitive performance from normal to dementia underwent florbetapir amyloid PET and blood collection.
Amplicon high-throughput sequencing of 16S ribosomal RNA (rRNA) gene is currently the most widely used technique to investigate complex gut microbial communities. Microbial identification might be influenced by several factors, including the choice of bioinformatic pipelines, making comparisons across studies difficult. Here, we compared four commonly used pipelines (QIIME2, Bioconductor, UPARSE and mothur) run on two operating systems (OS) (Linux and Mac), to evaluate the impact of bioinformatic pipeline and OS on the taxonomic classification of 40 human stool samples.
View Article and Find Full Text PDF