Optimization of the diagnosis and characterization of gibberellin-regulated protein sensitization: An Italian cohort study.

Background: Pru p 7 was the first gibberellin-regulated protein (GRP) to be identified as a food allergen as the basis of a pollen food allergy syndrome.

Objective: To clinically and biologically characterize a group of patients with suspected allergy to Pru p 7 to optimize the diagnostic workup of GRP sensitization.

Methods: Allergy to Pru p 7 was suspected in the presence of a systemic allergic reaction to plant food, positive skin prick test results for cypress pollen and lipid-transfer protein-enriched peach extract, and absence of Pru p 3-specific immunoglobulin E.

Allergies and COVID-19 vaccines: An ENDA/EAACI Position paper.

Background: Anaphylaxis, which is rare, has been reported after COVID-19 vaccination, but its management is not standardized.

Method: Members of the European Network for Drug Allergy and the European Academy of Allergy and Clinical Immunology interested in drug allergy participated in an online questionnaire on pre-vaccination screening and management of allergic reactions to COVID-19 vaccines, and literature was analysed.

Results: No death due to anaphylaxis to COVID-19 vaccines has been confirmed in scientific literature.

Omalizumab for prevention of anaphylactic episodes in a patient with severe mosquito allergy.

Anaphylaxis after mosquito bite is rare, but life threatening. No approved preventive therapy is available to date, but omalizumab could be a promising therapeutic option for reducing risk and improving quality of life in these patients.

Large local reactions to Hymenoptera stings: Outcome of re-stings in real life.

Background: Large local reaction to Hymenoptera stings is usually defined as a swelling >10 cm which lasts longer than 24 hours, sometimes associated with erythema, pruritus and blisters. Currently, the risk of subsequent systemic reactions after re-stings is considered low (2%-15%). Therefore, a diagnostic workup in case of large local reaction is often judged unnecessary, as well as adrenaline auto-injector and venom immunotherapy prescription.

immunotherapy versus -venom immunotherapy in allergy: a comparison study in field re-stings.

Background: In ascertained allergic sensitization to (VC) venom, the European guidelines still consider venom immunotherapy (VIT) with (VE) venom sufficient to achieve an adequate protection against VC. However, antigen 5 immunoblotting studies showed that a genuine sensitization to VC venom may exist. In such cases, a specific VC venom would be preferable for VIT treatment.

Upper Digestive Bleeding in Atrial Fibrillation: Evaluation of Gastroscopy Prior to Oral Anticoagulant Therapy (GOAT), Prospective, Randomized, Double Blind Study on a Community Population.

Background: The aim of this study was to investigate the incidence of digestive hemorrhages in patients with non-valvular atrial fibrillation (NVAF), scheduled for oral anticoagulant therapy.

Methods: We conducted, over 24 months, a prospective, randomized, population-based observational study on consecutive patients with recurrent paroxysmal, persistent, or permanent NVAF, scheduled for oral anticoagulant therapy. The study initially included 268 patients with NVAF (162 males and 106 females) with a mean age of 74 years (range 42-86 years).

Outcome of patients with elevated cardiac troponin I level after mild trauma.

The objective of this study was to evaluate whether increased c-Tnl in patients suffering from mild trauma without cardiac disease may be prognostic for future cardiac events. Consecutive patients suffering from mild trauma were recruited and evaluated for levels of creatinine, creatine-kinase (CK) and c-Tnl. Patients with elevated c-Tnl were selected and followed up for six months for cardiac events (cardiac death, Myocardial Infarction, Acute Coronary Syndromes, cardiac syncope, pacemaker or Intracardiac Device Implantation, Percutaneous Cardiac Intervention, and aortic-coronary bypass).