Publications by authors named "Elisa Massardi"
Int J Mol Sci
October 2020
Article Synopsis
- The study examines how hemin interacts with different lengths of prion protein fragments that contain histidine, linking it to prion diseases and potential brain injuries.
- Hemin forms a 1:1 complex with prion peptides, showing stronger binding as the number of histidines and the length of the peptide increase, with specific binding constants calculated for some fragments.
- The hemin-prion complexes tend to aggregate, reducing solubility and potentially contributing to oxidative stress in neurons, which could play a role in neurodegenerative diseases.
