Publications by authors named "Elisa Maria Dorantes-Acosta"
Introduction: The mechanistic/mammalian target of rapamycin (mTOR) is a serine/threonine kinase, which is downregulated or upregulated and is implicated in different types of cancer including hematologic neoplasms, skin prostate, and head and neck cancer.
Aim: The aim of this study was to explore the current knowledge of mTOR signaling in acute lymphoblastic leukemia and Hodgkin lymphoma.
Methods: A systematic review was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, searching PubMed, Discovery Service for National Autonomous University of Mexico, Registro Nacional de Instituciones y Empresas Científicas y Tecnológicas (RENIECYT), and Scientific Electronic Library Online (SciELO) from 1994 to 2023.
Overweight and obesity as predictors of early mortality in Mexican children with acute lymphoblastic leukemia: a multicenter cohort study.
BMC Cancer
July 2019
Article Synopsis
- Mexico City has a high incidence and mortality rate of acute lymphoblastic leukemia (ALL), with a noted rise in childhood obesity, which is linked to worse outcomes in these patients.
- A study analyzed 1,070 children under 15 diagnosed with ALL to determine if obesity/overweight predicted early mortality and relapse within the first 24 months.
- Results indicated that being overweight or obese at diagnosis significantly increased the risk of early mortality, but there was no strong association found between these conditions and early relapse rates.
Background And Aims: Occupational exposure of parents to carcinogens is of great interest in the etiology of leukemias. Evidence of the impact of such exposure on infants or small children is scarce. Here we estimated whether occupational exposure of parents to carcinogens could be a risk factor for leukemias in their children.
View Article and Find Full Text PDFEarly mortality in children with acute lymphoblastic leukemia in a developing country: the role of malnutrition at diagnosis. A multicenter cohort MIGICCL study.
Leuk Lymphoma
April 2017
The role of malnutrition at diagnosis as a predictor of early mortality in Mexican leukemia children remains controversial. The objective of present study was to investigate whether malnutrition was a predictor of early mortality during the first year of treatment in Mexican acute lymphoblastic leukemia (ALL) children through the first population-based study. A total of 794 newly diagnosed ALL pediatric patients from public hospitals of Mexico City were enrolled.
View Article and Find Full Text PDFCytarabine is one of the most effective antineoplastic agents among those used for the treatment of acute myeloid leukemia. However, some patients develop resistance and/or severe side effects to the drug, which may interfere with the efficacy of the treatment. The polymorphisms of some Ara-C metabolizing enzymes seem to affect outcome and toxicity in AML patients receiving cytarabine.
View Article and Find Full Text PDFPrevalence of gene rearrangements in Mexican children with acute lymphoblastic leukemia: a population study-report from the Mexican Interinstitutional Group for the identification of the causes of childhood leukemia.
Biomed Res Int
September 2015
Article Synopsis
- Mexico has a high rate of childhood leukemia, with worse mortality rates compared to other countries, potentially linked to specific gene rearrangements in acute lymphoblastic leukemia (ALL).
- A study conducted at eight public hospitals from 2010 to 2012 analyzed 282 bone marrow samples to identify the prevalence of four key gene rearrangements: ETV6-RUNX1, TCF3-PBX1, BCR-ABL1, and MLL.
- Gene rearrangements were found in 17.7% of patients, with a correlation between specific rearrangements and early deaths within the first few months of diagnosis, indicating a possible connection to the aggressive nature of leukemia in these children.
Background: Worldwide, acute leukemia is the most common type of childhood cancer. It is particularly common in the Hispanic populations residing in the United States, Costa Rica, and Mexico City. The objective of this study was to determine the incidence of acute leukemia in children who were diagnosed and treated in public hospitals in Mexico City.
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