Publications by authors named "Elisa Linnea Lindfors Rossi"
Article Synopsis
- The study aimed to determine the prevalence of latent tuberculosis infection (LTBI) in patients with acute leukemia (AL) using the QuantiFERON (QFT)-TB test, as there's no established screening program for such patients in low TB incidence countries.
- A total of 62 AL patients were screened, with 11.3% testing positive for LTBI, and no patients showing symptoms of active TB during the observation period.
- The findings suggest that LTBI may be more prevalent in Italy than previously thought, highlighting the need for TB screening before starting treatment in AL patients, especially as new treatment options become available.
Vitamin C has been shown to play a significant role in suppressing progression of leukemia through epigenetic mechanisms. We aimed to study the role of vitamin C in acute myeloid leukemia (AML) biology and clinical course. To this purpose, the plasma levels of vitamin C at diagnosis in 62 patients with AML (including 5 cases with acute promyelocytic leukemia, APL),7 with myelodysplastic syndrome (MDS), and in 15 healthy donors (HDs) were studied.
View Article and Find Full Text PDFThe terminal deoxynucleotidyl transferase (TdT) is a DNA polymerase expressed in acute myeloid leukemias (AMLs), where it may be involved in the generation of NPM1 and FLT3-ITD mutations. We studied the correlations between TdT expression and FLT3-ITD or NPM1 mutations in primary AML samples, and the impact on patients' survival. TdT expression was analyzed in 143 adult AML patients by flow cytometry as percentage of positivity and mean fluorescence intensity (MFI) on blasts.
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