Synopsis of recent research by authors named "Elisa Lehnert"
- Elisa Lehnert's research primarily focuses on the structure and function of the transporter associated with antigen processing (TAP) and its role in the immune response, particularly in the context of how antigenic peptides are processed and presented by major histocompatibility complex class I molecules.
- Her studies employ advanced techniques such as dynamic nuclear polarization enhanced solid-state NMR spectroscopy to investigate the interactions between TAP and antigenic peptides, revealing critical insights into the mechanisms of peptide translocation and loading onto MHC I.
- Additionally, her work includes the development of sensitive quantification methods to analyze TAP-dependent antigen compartmentalization in immune cells, enhancing our understanding of the peptide presentation process essential for T cell activation and self-tolerance.
