Oxidative stress biomarkers in patients with untreated obstructive sleep apnea syndrome.

Background: The pathogenic role of oxidative stress in obstructive sleep apnea syndrome (OSAS) is still a matter of debate, with different studies obtaining contrasting results.

Methods: The aim of the present study was to evaluate three well-known markers of oxidative stress (advanced oxidation protein products [AOPP], ferric reducing antioxidant power [FRAP], and total glutathione [GSH]) in a cohort of 41 untreated patients with a new diagnosis of OSAS.

Results: We observed that OSAS patients showed increased protein oxidative damage and impaired antioxidant defenses.

Clock T3111C and Per2 C111G SNPs do not influence circadian rhythmicity in healthy Italian population.

A possible relationship between human circadian rhythmicity and polymorphisms in clock genes have been documented. However, these data are controversial, and studies both corroborating and denying them have been reported. T3111C Clock polymorphism had been associated with the human evening preference, however, this association has not been confirmed.