Publications by authors named "Elisa Carlani"
Background: The long-term outcomes of esophageal peroral endoscopic myotomy (POEM) are still unknown.
Methods: We searched electronic databases (MEDLINE/PubMed, EMBASE, Scopus) for studies assessing outcomes after POEM for esophageal achalasia with a minimum median follow-up duration of 36 months. Pooled rates of clinical success and postoperative reflux were calculated and compared with the same values at 12/24/36 months when available.
Extraesophageal reflux symptoms are increasingly common in the Western population and their clinical management is still controversial. Although therapy with proton-pump inhibitors (PPIs) represents the gold standard, to date, many patients are refractory to this treatment. The aim of this study was to evaluate, in patients with a recent diagnosis of GERD experiencing extraesophageal symptoms, the efficacy and safety of a 6-week treatment with PPI acid suppression in combination with Gerdoff (a hyaluronic acid and chondroitin sulphate-based medical device) compared to PPI monotherapy.
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- - Eosinophilic esophagitis (EoE) is a chronic disease affecting the esophagus, marked by symptoms of esophageal dysfunction and inflammation caused by eosinophils; its incidence is increasing and can lead to serious complications if untreated.
- - The causes of EoE are complex, involving genetics, environmental factors, and immune responses, and understanding these mechanisms is essential for developing new treatments.
- - This review discusses the main factors contributing to EoE, focusing on type 2 inflammation and its cellular components, and highlights past therapeutic approaches while suggesting potential future targets for therapy.
Aim: Surgical myotomy of the lower esophageal sphincter has a 5-year success rate of approximately 91 %. Peroral endoscopic myotomy can provide similar results for controlling dysphagia. Some patients experience either persistent or recurrent dysphagia after myotomy.
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