p53-Mediated oxidative stress and tubular injury in rats with glycerol-induced acute kidney injury.

Background/aims: p53 is a transcriptional factor that responds to severe cell damage promoting the transcription of proapoptotic and prooxidant genes. In this study, we evaluated the role of p53 activation in glycerol-induced acute kidney injury (Gly-AKI).

Methods: Rats were treated with p53 inhibitor (pifithrin-α) in the moment we injected glycerol.