Publications by authors named "Elin M Svenson"
Effect of Interindividual Variability in Metabolic Clearance and Relative Bioavailability on Rifampicin Exposure in Tuberculosis Patients with and without HIV Co-Infection: Does Formulation Quality Matter?
Glauco Henrique Balthazar Nardotto Elin M Svenson Valdes Roberto Bollela Adriana Rocha Svetoslav Nanev Slavov
Pharmaceutics
July 2024
Article Synopsis
- The study investigates how rifampicin (RIF) behaves in the bodies of tuberculosis patients, both with and without HIV, focusing on its metabolite, 25-O-desacetyl-rifampicin (desRIF).
- Researchers analyzed data from 33 TB patients on RIF treatment and found that HIV co-infection does not affect RIF levels in the blood, and desRIF formation does not account for variability in its disposition.
- Results indicated that RIF had lower effectiveness than expected, especially in patients weighing less than 50 kg, suggesting that the formulation of the drug leads to reduced absorption in the body.