Regulation of arcuate genes by developmental exposures to endocrine-disrupting compounds in female rats.

Developmental exposure to endocrine-disrupting compounds (EDCs) alters reproduction and energy homeostasis, both of which are regulated by the arcuate nucleus (ARC). Little is known about the effects of EDC on ARC gene expression. In Experiment #1, pregnant dams were treated with either two doses of bisphenol A (BPA) or oil from embryonic day (E)18-21.

Oxidative stress responses and recovery patterns in the liver of Oreochromis niloticus exposed to chlorpyrifos-ethyl.

Chlorpyrifos is the most common insecticide in freshwater ecosystems, and detected in agricultural and fishery product. In this study, Oreochromis niloticus were exposed to 5, 10 and 15 ppb sublethal concentrations of chlorpyrifos in order to determine the oxidative stress response in liver. Acetylcholinesterase (AChE) activity was significantly inhibited.

Effects of diazinon on antioxidant defense system and lipid peroxidation in the liver of Cyprinus carpio (L.).

Diazinon is a widely used organophosphorus pesticide in agriculture and environmental health, hence its adverse effects on nontarget animals, especially on fish is to be determined. The present study therefore aimed at detecting the biochemical changes caused by diazinon. To accomplish this aim, we studied the effects of sublethal concentrations (0.

Evaluation of oxidative stress responses and neurotoxicity potential of diazinon in different tissues of Cyprinus carpio.

Toxicity of organophosphorus insecticides is mainly due to the inhibition of acetylcholinesterase, but, oxidative stress may be involved in the toxicity of this pesticides. Therefore, it was investigated whether diazinon, a commonly used organophosphate, may induce oxidative stress and cholinesterase inhibition in different tissues of Cyprinus carpio. Sublethal concentrations of diazinon (0.

Neurotoxicity evaluation of the organofluorine pesticide etoxazole in the brain of Oreochromis niloticus.

Etoxazole is a new organofluorine pesticide that has been used worldwide as acaricide and insecticide since 1998. Almost no previous attempt has been made to evaluate the toxic effects of etoxazole in vertebrates. Using fish (Oreochromis niloticus) as a suitable model organism, the aim of this study was to indicate whether etoxazole affects acetylcholinesterase and sodium potassium-activated adenosine triphosphatase activities in the brain tissue in order to evaluate the impacts on neurotoxicity and ion transportation.

Effects of diazinon on acetylcholinesterase activity and lipid peroxidation in the brain of Oreochromis niloticus.

The aim of this study was to investigate the effects of organophosphorus (OP) pesticide diazinon on acetylcholinesterase (AChE: EC 3.1.1.

Oxidative stress-related and ATPase effects of etoxazole in different tissues of Oreochromisniloticus.

The aim of this study is to evaluate the effects of etoxazole, a new organofluorine acaricide-insecticide, on antioxidant enzyme activities, malondialdehyde content, and different adenosine triphosphatase (ATPase) activities in the gill, kidney and muscle tissues of freshwater fish, Oreochromisniloticus. Superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), Na(+), K(+)adenosine triphosphatase, Mg(2+)adenosine triphosphatase, Ca(2+)adenosine triphosphatase activities, and malondialdehyde (MDA) were measured spectrophotometrically in whole tissue homogenates of fish exposed to five different sublethal etoxazole concentrations (0.27, 0.

Marker enzyme assessment in the liver of cyprinus carpio (L.) exposed to 2,4-D and azinphosmethyl.

The potential utility of antioxidant enzymes and lipid peroxidation as indicators of exposure to 2,4-D and azinphosmethyl together with the toxic effects of these compounds in freshwater fish Cyprinus carpio were evaluated. Biochemical parameters were recorded spectrophotometrically in fish liver, which were exposed to a single dose of 2,4-D and azinphosmehtyl (1/3 LC(50)), and their mixture at 1:1 ratio for 24, 48, 72, and 96 h. The most sensitive parameter was glutathione S-transferase (GST) activity, which significantly increased with experimental exposures.