Dtsch Med Wochenschr
December 2024
Since its founding 150 years ago, the Deutsche Medizinische Wochenschrift has continually followed the developments in nephrology through countless publications. Pioneers in nephrology like Franz Volhard and Georg Haas were authors of the DMW, and new hypotheses, examination methods, and therapies were often debated here, as this article shows.
View Article and Find Full Text PDFBackground: Cardioprotective interventions-such as pharmacological postconditioning-are a promising strategy to reduce deleterious consequences of ischemia and reperfusion injury (I/RI) in the heart, especially as timing and onset of myocardial infarction are unpredictable. Pharmacological postconditioning by treatment with dexmedetomidine (Dex), an α2-adrenoreceptor agonist, during reperfusion protects hearts from I/RI, independently of time point and duration of application during the reperfusion phase. The mitochondrial ATP-sensitive K (mKATP) and mitochondrial large-conductance calcium-sensitive potassium channel (mBKCa) play a pivotal role in mediating this cardioprotective effect.
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