Anti-cancer activity of a novel palladium(II) complex on human breast cancer cells in vitro and in vivo.

Anti-cancer effects of a newly-synthesized palladium(II) complex, [Pd(sac)(terpy)](sac)·4H(2)O (sac = saccharinate, and terpy = 2,2':6',2''-terpyridine), were tested against human breast cancer cell lines, MCF-7 and MDA-MB-231. The Pd complex had a strong anti-growth effect in a dose- and time-dependent manner in vitro. This effect was also confirmed by the experiment performed on Balb/c mice in vivo.