Synthesis of N-phenylsulfonamide derivatives and investigation of some esterase enzymes inhibiting properties.

In this study, synthesis of nine N-phenylsulfonamide derivatives was designed by starting from aniline, which is the simplest aromatic amine. These compounds were obtained in yields between 69 and 95%. Inhibitory properties of synthesized compounds on carbonic anhydrase I (CA I), CA II isoenzymes, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes were investigated.

Photooxygenation of azidoalkyl furans: catalyst-free triazole and new endoperoxide rearrangement.

Photooxygenation of azidoalkyl furans has revealed both a novel triazole formation method and a unique endoperoxide rearrangement. The key step of this method is a 3 + 2 cycloaddion of the azide to the endoperoxide intermediate. The reduction of the peroxide bond and two subsequent C-C bond cleavages provide a triazole having a newly formed carboxylic acid functionality.

Simple methanesulfonates are hydrolyzed by the sulfatase carbonic anhydrase activity.

The possible sulfatase activity of several carbonic anhydrase (CA, EC 4.2.1.