Multidrug Resistance Genomic Island 1 in a subsp. Human Clinical Isolate from France.

genomic island 1 (SGI1) is a multidrug resistance integrative mobilizable element that harbors a great diversity of antimicrobial resistance gene clusters described in numerous serovars and also in . A serious threat to public health was revealed in the recent description in of a SGI1-derivative multidrug resistance island named PGI1 ( genomic island 1) carrying extended-spectrum-β-lactamase (ESBL) and metallo-β-lactamase resistance genes, and , respectively. Here, we report the first description of genomic island 1 (SGI1) in a multidrug-resistant clinical subsp.

Detection of SGI1/PGI1 Elements and Resistance to Extended-Spectrum Cephalosporins in of Animal Origin in France.

, and especially , are often the cause of urinary tract infections (UTIs) in humans. They were reported as carriers of extended-spectrum β-lactamase (ESBL) genes, and recently of carbapenemases, mostly carried by the genomic island 1 (SGI1) and genomic island 1 (PGI1). have also lately become an increasing cause of UTIs in companion animals, but antimicrobial susceptibility data in animals are still scarce.

Survey of multidrug resistance integrative mobilizable elements SGI1 and PGI1 in Proteus mirabilis in humans and dogs in France, 2010-13.

Objectives: To characterize MDR genomic islands related to Salmonella genomic island 1 (SGI1) and Proteus genomic island 1 (PGI1) in Proteus mirabilis from human and animal sources in France in light of the previously reported cases.

Methods: A total of 52 and 46 P. mirabilis clinical strains from human and animal sources, respectively, were studied for the period 2010-13.