Publications by authors named "Eliete de Souza Von Zuben"
Hydroxyethylcellulose-Based Hydrogels Containing Liposomes Functionalized with Cell-Penetrating Peptides for Nasal Delivery of Insulin in the Treatment of Diabetes.
Pharmaceutics
November 2022
Article Synopsis
- * Tests showed that these formulations maintain desirable properties like pseudoplastic behavior, meaning they can flow easily while remaining stable, making them suitable for nasal delivery.
- * The study found that the liposomal formulations improved insulin retention compared to traditional methods, achieving better absorption and higher serum insulin levels, indicating their potential effectiveness for nasal insulin delivery.
Insulin is an important anabolic hormone that regulates the metabolism of carbohydrates, lipids and proteins. In this study, a reverse-phase liquid chromatography (RP-LC) method was successfully validated and tested for the encapsulation efficiency assay of insulin and in vitro release studies. HPLC analyses were carried out using a RP C18- Luna® Phenomenex (4.
View Article and Find Full Text PDFMethotrexate (MTX) is an immunosuppressive drug for systemic use in the treatment of skin diseases, however, MTX presents a number of side effects, such as hepatotoxicity. To overcome this limitation, this study developed skin MTX delivery surfactant systems, such as a microemulsion (ME) and a liquid crystalline system (LCS), consisting of a glycol copolymer-based silicone fluid (SFGC) as oil phase, polyether functional siloxane (PFS) as surfactant, and carbomer homopolymer type A (C971) dispersion at 0.5% (wt/wt) as aqueous phase.
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