Publications by authors named "Elieser Hitoshi Watanabe"
Introduction: The profile of genetic and nongenetic factors associated with progression to kidney failure (KF) in steroid-resistant nephrotic syndrome (SRNS) is largely unknown in admixed populations.
Methods: A total of 101 pediatric patients with primary SRNS were genetically assessed targeting Mendelian causes and status with a 62-NS-gene panel or whole exome sequencing, as well as genetic ancestry. Variant pathogenicity was evaluated using the American College Medical of Genetics and Genomics (ACMG) criteria.
Minimal Change Disease and Focal Segmental Glomerulosclerosis are associated with good kidney prognosis and Thrombotic Microangiopathy with poor kidney survival in patients with COVID-19-associated nephropathies.
Am J Nephrol
December 2024
Article Synopsis
- * Among 94 patients, most were male and half had a history of hypertension; commonly observed kidney issues included collapsing glomerulopathy (CG), focal segmental glomerulosclerosis (FSGS), and thrombotic microangiopathy (TMA).
- * Results indicated that FSGS and minimal change disease (MCD) were linked to better kidney survival compared to TMA, underscoring differences in kidney complications resulting from COVID-19 within this patient group.
Podocytopathies associated with familial partial lipodystrophy due to LMNA variants: report of two cases.
Arch Endocrinol Metab
May 2024
Article Synopsis
- * Two cases of FPLD were reported, where Patient 1 had a specific LMNA mutation and developed kidney issues, while Patient 2, with a different mutation, experienced worsening kidney function over time.
- * Both patients showed hyperinsulinemia but no diabetes, highlighting the need for ongoing monitoring of kidney health in individuals with FPLD due to the variable effects linked to LMNA mutations.
Clinical, tomographic and functional comparison of sporadic and tuberous sclerosis complex-associated forms of lymphangioleiomyomatosis: a retrospective cohort study.
ERJ Open Res
March 2024
Article Synopsis
- Lymphangioleiomyomatosis (LAM) can present in two forms—sporadic (S-LAM) and associated with tuberous sclerosis complex (TSC-LAM)—and the study aims to compare their clinical and functional differences.
- A total of 107 patients were analyzed between 1994 and 2019, revealing that while TSC-LAM patients had more associated health issues, both groups had similar pulmonary function tests.
- The study found that S-LAM patients experience a greater decline in lung function and more lung cysts, while TSC-LAM impacts quality of life more significantly, especially regarding vitality and emotional health.
The present study aimed to evaluate the effectiveness of the application of photobiomodulation therapy (PBMT) in the prevention of recurrent herpes labialis (RHL) through a randomized controlled clinical trial. RHL is a lifelong infection that effects patients' quality of life. In the literature PBMT has shown positive results preventing RHL, decreasing recurrences and severity of lesions.
View Article and Find Full Text PDFLipoprotein glomerulopathy associated with the Osaka/Kurashiki APOE variant: two cases identified in Latin America.
Diagn Pathol
July 2021
Article Synopsis
The effect of sirolimus on angiomyolipoma is determined by decrease of fat-poor compartments and includes striking reduction of vascular structures.
Sci Rep
April 2021
Renal angiomyolipomas hemorrhage is associated with their size and vascular constitution. The effects of sirolimus on different components of angiomyolipomas was analyzed in patients with tuberous sclerosis complex, sporadic lymphangioleiomyomatosis and multiple sporadic angiomyolipomas. Thirty angiomyolipomas from 14 patients treated with sirolimus were retrospectively evaluated.
View Article and Find Full Text PDFBrazilian Consortium for the Study on Renal Diseases Associated With COVID-19: A Multicentric Effort to Understand SARS-CoV-2-Related Nephropathy.
Front Med (Lausanne)
October 2020
Kidney involvement appears to be frequent in coronavirus disease 2019 (COVID-19). Despite this, information concerning renal involvement in COVID-19 is still scarce. Several mechanisms appear to be involved in the complex relationship between the virus and the kidney.
View Article and Find Full Text PDFA Specific Polymorphic Genotype Modulates the Risk of Parasitemia While , , and Variant Profiles and HIV Infection Protect Against Cardiomyopathy in Chagas Disease.
Front Immunol
April 2021
Background: Chagas disease caused by () affects approximately six million individuals worldwide. Clinical manifestations are expected to occur due to the parasite persistence and host immune response. Herein we investigated potential associations between , , , or polymorphism profiles and cardiomyopathy or parasitemia, as well as the impact of HIV infection on cardiopathy.
View Article and Find Full Text PDFBackground: Cyst infection is a prevalent complication in autosomal dominant polycystic kidney disease (ADPKD) patients, however therapeutic and diagnostic approaches towards this condition remain unclear. The confirmation of a likely episode of cyst infection by isolating the pathogenic microorganism in a clinical scenario is possible only in the minority of cases. The available antimicrobial treatment guidelines, therefore, might not be appropriate to some patients.
View Article and Find Full Text PDFA novel single amino acid deletion impairs fibronectin function and causes familial glomerulopathy with fibronectin deposits: case report of a family.
BMC Nephrol
August 2019
Background: Glomerulopathy with fibronectin deposits is an autosomal dominant disease associated with proteinuria, hematuria, hypertension and renal function decline. Forty percent of the cases are caused by mutations in FN1, the gene that encodes fibronectin.
Case Presentation: This report describes two cases of Glomerulopathy with fibronectin deposits, involving a 47-year-old father and a 14-year-old son.