Publications by authors named "Elien Lecomte"
Article Synopsis
- Hereditary neurologic diseases in adults have high clinical and molecular diversity, making diagnosis challenging; this study evaluates the effectiveness of exome sequencing (ES) in diagnosing these conditions.
- Conducted at Ghent University Hospital from 2019 to 2022, the study tested 1,411 patients using multipanel ES, focusing on various neurological disorders and analyzing genetic variants across 725 genes.
- A molecular diagnosis was achieved in 10% of cases, with the highest success rate in ataxia patients, revealing new genetic variants and highlighting that ES is a valuable diagnostic approach for adult-onset neurologic disorders.
Yellow fever (YF) causes high fever, liver dysfunction, renal failure, hypercoagulopathy and platelet dysfunction and can lead to shock and death with a case-fatality ratio of 20-50%. YF vaccination results in long-lasting protective immunity. Serious adverse events (SAEs), such as YF vaccine-associated neurotropic disease (YEL-AND) are rare.
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