Pro-Oxidant and Cytotoxic Effects of Tucum-Do-Cerrado ( Mart.) Extracts in Colorectal Adenocarcinoma Caco-2 Cells.

Colorectal cancer is one of the most common types of cancer. Bioactive natural compounds can act in cancer chemoprevention as tumor growth inhibitors. Tucum-do-cerrado ( Mart.

Compounds of tucum-do-cerrado () fruit with antioxidant activity.

'Tucum-do-cerrado' () is an edible fruit from the Brazilian 'Cerrado' biome marked by a high antioxidant potential and polyphenol content when compared to other fruits from the same biome. Its antioxidant activity is higher in the peel than in the pulp. Ethanolic and aqueous peel extracts were analyzed by the ferric reducing antioxidant power (FRAP) assay.

Cell density-dependent linoleic acid toxicity to Saccharomyces cerevisiae.

Since the discovery of the apoptotic pathway in Saccharomyces cerevisiae, several compounds have been shown to cause apoptosis in this organism. While the toxicity of polyunsaturated fatty acids (PUFA) peroxides towards S. cerevisiae has been known for a long time, studies on the effect of nonoxidized PUFA are scarce.

The yeast genome may harbor hypoxia response elements (HRE).

The hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription factor activated when cells are submitted to hypoxia. The heterodimer is composed of two subunits, HIF-1alpha and the constitutively expressed HIF-1beta. During normoxia, HIF-1alpha is degraded by the 26S proteasome, but hypoxia causes HIF-1alpha to be stabilized, enter the nucleus and bind to HIF-1beta, thus forming the active complex.

Cytotoxic effects of Cochlospermum regium (Mart & Schrank) Pilger aqueous root extract on mammalian cells.

We investigated the effect of Cochlospermum regium (Mart & Schrank) Pilger aqueous root extract on Chinese hamster ovarian (CHO)-K1 cells. The extract significantly decreased proliferation of CHO-K1 cells (EC(50)=1.5mg/mL).