Erratum: Publisher Correction: Genetic interaction networks mediate individual statin drug response in .

[This corrects the article DOI: 10.1038/s41540-019-0112-5.].

Genetic interaction networks mediate individual statin drug response in .

Eukaryotic genetic interaction networks (GINs) are extensively described in the S288C model using deletion libraries, yet being limited to this one genetic background, not informative to individual drug response. Here we created deletion libraries in three additional genetic backgrounds. Statin response was probed with five queries against four genetic backgrounds.

N,N-Bis(glycityl)amines as anti-cancer drugs.

A series of N,N-bis(glycityl)amines with promising anti-cancer activity were prepared via the reductive amination of pentoses and hexoses, and subsequently screened for their ability to selectively inhibit the growth of cancerous versus non-cancerous cells. For the first time, we show that this class of compounds possesses anti-proliferative activity, and, while the selective killing of brain cancer (LN18) cells versus matched (SVG-P12) cells was modest, several of the amines, including d-arabinitylamine 1a and d-fucitylamine 1g, exhibited low micromolar IC50 values for HL60 cells. Moreover, these two amines showed good selectivity towards HL60 cells when compared to non-cancerous HEK-293 cells.