Electromechanical interactions between cell membrane and nuclear envelope: Beyond the standard Schwan's model of biological cells.

We investigate little-appreciated features of the hierarchical core-shell (CS) models of the electrical, mechanical, and electromechanical interactions between the cell membrane (CM) and nuclear envelope (NE). We first consider a simple model of an individual cell based on a coupled resistor-capacitor (Schwan model (SM)) network and show that the CM, when exposed to ac electric fields, acts as a low pass filter while the NE acts as a wide and asymmetric bandpass filter. We provide a simplified calculation for characteristic time associated with the capacitive charging of the NE and parameterize its range of behavior.