Publications by authors named "Elias P Makhoul"
Background: Sacituzumab govitecan, targeting trophoblast cell-surface antigen 2 (TROP2), is approved for the treatment of triple-negative and hormone receptor-positive/HER2-negative breast cancers. However, detailed studies comparing TROP2 protein expression in the different molecular subtypes of breast cancer are limited, and definitive evidence supporting the use of TROP2 as a biomarker for predicting response to this agent in patients with breast cancer is currently lacking.
Objective: To compare the expression of TROP2 in the different molecular subtypes of breast cancer.
Article Synopsis
- - Serrated epithelial change (SEC) occurs in patients with long-term inflammatory bowel disease (IBD), showing irregular crypt structures and a high number of goblet cells, and is linked to an increased risk of colorectal cancer.
- - A study analyzed genetic mutations in SEC, finding that TP53 mutations were common and linked to various stages of dysplasia and adenocarcinoma, while mutations in KRAS/BRAF were more prevalent in control serrated lesions.
- - The relationship between SEC and IBD-related cancer is still uncertain, and the research used targeted next-generation sequencing to investigate genetic changes in SEC and associated lesions in patients with IBD.
Aims: Gastric dysplasia is a risk factor for synchronous and subsequent gastric carcinoma. Distinguishing gastric dysplasia from reactive changes is subject to interobserver disagreement and is a frequent reason for expert consultation. We previously used assessment of surface cell polarity (the 'four lines') as a key feature to decrease equivocal diagnoses in Barrett oesophagus.
View Article and Find Full Text PDF