Publications by authors named "Elias Baumann"
Article Synopsis
- This study explores the significance of tumor budding (TB) in colorectal cancer, particularly focusing on intratumoral budding (ITB) in resection specimens and its feasibility in biopsy samples.* -
- The research found that high-grade TB, whether intratumoral or peritumoral, is linked with worse outcomes such as advanced cancer stages and lower overall survival rates.* -
- Results indicated that ITB is a strong predictor of overall survival and can help in improving risk assessment and predicting responses to neoadjuvant therapy in cancer patients, highlighting the need for TB evaluation in biopsies.*
Nuclear detection, segmentation and morphometric profiling are essential in helping us further understand the relationship between histology and patient outcome. To drive innovation in this area, we setup a community-wide challenge using the largest available dataset of its kind to assess nuclear segmentation and cellular composition. Our challenge, named CoNIC, stimulated the development of reproducible algorithms for cellular recognition with real-time result inspection on public leaderboards.
View Article and Find Full Text PDFTumor cell fraction (TCF) estimation is a common clinical task with well-established large interobserver variability. It thus provides an ideal test bed to evaluate potential impacts of employing a tumor cell fraction computer-aided diagnostic (TCFCAD) tool to support pathologists' evaluation. During a National Slide Seminar event, pathologists (n = 69) were asked to visually estimate TCF in 10 regions of interest (ROIs) from hematoxylin and eosin colorectal cancer images intentionally curated for diverse tissue compositions, cellularity, and stain intensities.
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