Background: Helicobacter pylori (H. pylori), is a common infection in pregnant women accompanied by variations in the levels of the IgM, IgA and IgG antibody isotypes. The variations of anti-H.
15-30% of AIDS patients do not regain normal CD4(+) T cell levels after antiretroviral therapy, even when HIV-1 replication is successfully suppressed.
The study investigated 65 adult AIDS patients with controlled viral loads to explore reasons for immune recovery failure, focusing on HLA alleles.
Findings showed that carriers of HLA-A68 and HLA-B15 had significantly higher proportions of poor immune responses, with potential etiological contributions of 57.89% and 61.35%, respectively.