Publications by authors named "Elianne van Zandvoort"
Article Synopsis
- Impaired muscle relaxation is a significant characteristic of certain myopathies, with transcranial magnetic stimulation (TMS) effectively measuring this relaxation through its impact on corticospinal drive.
- Men with Brody disease, nemaline myopathy type 6, and myotonic dystrophy type 2 showed significantly lower peak relaxation rates compared to healthy individuals and symptomatic controls.
- TMS demonstrated high diagnostic accuracy in differentiating myopathy patients from controls, suggesting its potential utility in clinical settings for confirming diagnoses and monitoring disease progression.
Transcranial magnetic stimulation (TMS) of the motor cortex can be used during a voluntary contraction to inhibit corticospinal drive to the muscle and consequently induce involuntary muscle relaxation. Our aim was to evaluate the reproducibility and the effect of varying experimental conditions (robustness) of TMS-induced muscle relaxation. Relaxation of deep finger flexors was assessed in 10 healthy subjects (5 M, 5 F) using handgrip dynamometry with normalized peak relaxation rate as main outcome measure, that is, peak relaxation rate divided by (voluntary plus TMS-evoked)force prior to relaxation.
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