CXCR2 intrinsically drives the maturation and function of neutrophils in mice.

Neutrophils play a major role in the protection from infections but also in inflammation related to tumor microenvironment. However, cell-extrinsic and -intrinsic cues driving their function at steady state is still fragmentary. Using knock-out mice, we have evaluated the function of the chemokine receptor Cxcr2 in neutrophil physiology.