An Ecological and Miniaturized Biological Method for the Analysis of Daptomycin Potency.

Background: Physicochemical and microbiological methods are found in the literature for the analysis of daptomycin, an antimicrobial.

Objective: This paper brings a miniaturized turbidimetric microbiological method for analysis of daptomycin in lyophilized powder.

Methods: The method was performed using 96-well microplates, 4-h incubation, 2, 4 and 8 μg/mL, 7% Staphylococcus aureus ATCC 6538 IAL 2082, and BHI broth.