Drosophila UBE3A regulates satiety signaling through the Piezo mechanosensitive ion channel.

Angelman syndrome (AS) is a rare neurogenetic disorder characterized by developmental delays, speech impairments, ataxic movements, and in some cases, hyperphagic feeding behavior. Loss of function mutations, loss of expression from the maternal allele or absence of maternal UBE3A result in AS. Recent studies have established a connection between and the mechanosensitive ion channel , suggesting the potential role of UBE3A in the regulation of PIEZO channels.