Publications by authors named "Eli Andino-Frydman"
Changing environmental conditions necessitate rapid adaptation of cytoplasmic and nuclear volumes. We use the slime mold Dictyostelium discoideum, known for its ability to tolerate extreme changes in osmolarity, to assess which role nuclear pore complexes (NPCs) play in achieving nuclear volume adaptation and relieving mechanical stress. We capitalize on the unique properties of D.
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- Ferroptosis is a form of cell death linked to iron and lipid damage, showing potential for cancer treatment, particularly involving lipid peroxidation of specific fatty acids.
- GPX4 normally prevents ferroptosis by converting harmful lipid hydroperoxides into less harmful forms, making it a potential drug target whose sensitivity is not well understood.
- Research indicates that cancer cells cultured in 3D conditions produce fewer polyunsaturated fatty acids and more monounsaturated fatty acids, which can help them resist ferroptosis and reduce the effectiveness of GPX4 inhibitors.