Identification of miRNAs and the target genes related to male infertility and smoking using bioinformatics approaches.

The impact of smoking on male fertility has been extensively acknowledged. Many studies have shown that smoking reduces sperm production, motility and fertilizing capacity by increasing seminal oxidative stress and DNA damage. In this study, expression profiles of miRNAs and their predicted target genes, showing dysregulation in smokers and associated with male infertility, were obtained, using Gene Expression Omnibus (GEO) datasets.