Noninvasive Monitoring of Palmitoyl Hexapeptide-12 in Human Skin Layers: Mechanical Interaction with Skin Components and Its Potential Skincare Benefits.

Self-assembling peptides (SAPs) represent a rich source of building blocks that interact with biological structures. For instance, cosmetic SAPs like Palmitoyl hexapeptide-12 have gained increasing interest for their anti-aging properties. However, their short-term impact on the skin composition and mechanics remains unclear.

Self-assembly of short biopeptides onto skin tissue components studied using QCM-D.

Objective: To enable the discovery of more effective formulations for cosmetic and dermatological applications by understanding the interactions of widely used bioactive ingredients with skin biomolecular components.

Methods: Affinities of six common oligopeptide utilized in biomedical application to five primary skin biomolecules (collagen, elastin, laminin, fibronectin and hyaluronic acid) were measured by monitoring their adsorption and subsequent self-assembly using quartz crystal microbalance with dissipation (QCM-D).

Results: Chemical compositions of both the adsorbates (oligo peptides) and the substrates (skin constituents) influence the adsorption behaviour.

Distribution and fate of per- and polyfluoroalkyl substances (PFAS) in wastewater treatment facilities.

Anthropogenic compounds known as per- and polyfluoroalkyl substances (PFAS) represent a major class of contaminants of emerging concern composed of nearly 5000 chemicals. Many PFAS are persistent, bioaccumulative and toxic, and their widespread use makes their environmental distribution a growing concern. Wastewater treatment facilities (WWTFs) are a conduit of PFAS to the environment, integrating common household products from municipal sewage, industrial wastewater sources, septic materials, and firefighting wastewaters in effluent and sludge.