Neuroprotective Effect of Root Extracts of (Barberry) on Oxidative Stress on SH-SY5Y Cells.

Objectives: Oxidative stress plays a key role in chronic and acute brain disorders and neuronal damage associated with Alzheimer disease (AD) and other neurodegeneration symptoms. The neuroprotective effects of berberine and (barberry) root extract against apoptosis induced by hydrogen peroxide (HO) in the human SH-SY5Y cell line were studied.

Methods: The methanolic extraction of barberry root was performed using a maceration procedure.