Interaction of toll-like receptors and ACE-2 with different variants of SARS-CoV-2: A computational analysis.

Introduction: Computational studies were performed to investigate the unknown status of endosomal and cell surface receptors in SARS-CoV-2 infection. The interactions between Toll-like receptors (TLRs)- 4/7/8/9 or ACE2 receptor and different SARS-CoV-2 variants were investigated.

Methods: The RNA motifs for TLR7, TLR8 and a CpG motif for TLR9 were analyzed in different variants.