Publications by authors named "Elham Safadeh"
Article Synopsis
- Despite advances in cancer treatment, colorectal cancer (CRC) remains the third leading cause of cancer deaths, largely due to resistance to therapy and disease recurrence in patients.
- Research indicates that disruptions in hormone signaling and its interaction with other pathways may contribute to this resistance in CRC cells.
- This review explores the role of microRNAs (miRNAs) in hormone signaling related to drug resistance in CRC, highlighting their potential as targets for future treatments.
Sirtuins, a family of nicotinamide adenine dinucleotide (NAD)-dependent lysine deacetylases, are promising targets for anticancer treatment. Recently, we characterized a novel pan-sirtuin (SIRT) inhibitor, MC2494, displaying antiproliferative effects and able to induce death pathways in several human cancer cell lines and decrease tumor growth in vivo. Based on the chemical scaffold of MC2494, and by applying a structure-activity relationship approach, we developed a small library of derivative compounds and extensively analyzed their enzymatic action at cellular level as well as their ability to induce cell death.
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