SiO2 nanoparticles modified CPE as a biosensor for determination of i-motif DNA/Tamoxifen interaction.

Cytosine-rich DNA sequences can form a highly ordered structure known as i-motif in slightly acidic solutions. The stability of the folded i-motif structure is a good strategy to inhibit the telomerase reaction in cancer cells. The electrochemical biosensor was prepared by modifying carbon paste electrode with SiO2 nanoparticles to investigate drugs which can stabilize this structure.

Assessment of Tooth Preparation via Er:YAG Laser and Bur on Microleakage of Dentin Adhesives.

Objective: Microleakage can be responsible for tooth hypersensitivity, secondary caries, and the possibility of pathological pulp alterations in restored teeth. Recently, alternative methods for tooth preparation such as laser irradiation have been studied; but there are limited studies on primary teeth. The aim of this in vitro study was to compare the degree of microleakage of composite restorations prepared by Er:YAG laser and conventional bur preparation with two adhesive systems in primary teeth.