Publications by authors named "Elham Aghamohamadi"
Article Synopsis
- The study examines regulatory T cells (Tregs) in treated celiac disease (CD) patients compared to healthy controls, focusing on Treg frequency and various inflammatory mediators.* -
- Results showed that CD patients had significantly fewer Tregs and reduced granzyme B levels in their blood, while duodenal biopsies revealed increased CD25 and FoxP3 expression but decreased IL-10.* -
- The findings suggest ongoing inflammation in the intestines of CD patients despite a gluten-free diet, indicating a potential need for therapies aimed at improving Treg function.*
Background: Celiac disease (CeD) and inflammatory bowel disease (IBD) are accompanied by impaired immune responses. To study the immune regulation of these diseases, we evaluated the expression levels of pro-inflammatory (IL-8 and IL-17 A) and anti-inflammatory (IL-10) cytokines in intestinal biopsy specimens of CeD and IBD patients in comparison to healthy subjects.
Methods And Results: Intestinal biopsies were collected from 33 patients with IBD, 47 patients with CeD, and 20 healthy individuals.
Interleukin-15 (IL-15) is a key player in the pathogenesis of celiac disease (CD). We investigated the functional role of IL-15 in the process of epithelial cell phenotypic modification at different stages of CD. In this study, we looked for correlations between the mRNA levels in duodenal tissue and serum protein levels in a cohort of Iranian patients affected by CD based on the degree of histopathology.
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