A comprehensive survey of warfarin-induced hepatic toxicity using histopathological, biomarker, and molecular evaluation.

Warfarin finds human application as anticoagulant therapy. Warfarin usage can cause liver damage and hemorrhage. Besides functioning as anticoagulant and causing continuous bleeding of pests, the mechanism of toxicity of warfarin is unknown.

Protective effect of Moringa oleifera leaf ethanolic extract against uranyl acetate-induced testicular dysfunction in rats.

Uranyl acetate (UA) is used in civilian and military applications, predisposing it to wide dispersion in ecosystems. Using high-performance liquid chromatography, gas chromatography-mass spectrometry, and 2,2-Diphenyl-1-picrylhydrazyl scavenging radical analysis, we confirmed that Moringa oleifera leaf ethanolic extract (MLEE) is rich in biologically active phytochemicals. Thus, this study aims to investigate the possible defensive effect of MLEE against UA-induced testicular dysfunction.

Gum Arabic nanoformulation rescues neuronal lesions in bromobenzene-challenged rats by its antioxidant, anti-apoptotic and cytoprotective potentials.

Bromobenzene (BB) is a hazardous environmental contaminant because of its multiple routes of exposure and the toxicity of its bio-derivates. It could elicit neuronal alterations by stimulating redox imbalance and apoptotic pathways. Gum Arabic (GA) protected the hippocampus of a type 2 diabetic rat model from cognitive decline.

Circulating redox status in sheep naturally infected with Trichophyton verrucosum.

Trichophyton verrucosum is a zoophilic dermatophyte that causes skin inflammation. The present study aimed to evaluate the redox status in the blood of sheep clinically infected with T. verrucosum.

Can fig and olive ameliorate the toxicity induced by 2-nitropropane in some organs of mice? Role of inflammatory versus anti-inflammatory gene.

Objective: To investigate the efficacy of Fig fruit powder and olive on hepatic, renal and splenic injury induced by 2-nitropropane (2-NP) in mice, especially if they were used in combination.

Methods: A total of 40 adult BALB/c male mice weighting 25-30 g/each. Mice were categorized into five groups (8 each).

Enhancement of β-Glucan Biological Activity Using a Modified Acid-Base Extraction Method from .

Beta glucan (β-glucan) has promising bioactive properties. Consequently, the use of β-glucan as a food additive is favored with the dual-purpose potential of increasing the fiber content of food products and enhancing their health properties. Our aim was to evaluate the biological activity of β-glucan (antimicrobial, antitoxic, immunostimulatory, and anticancer) extracted from using a modified acid-base extraction method.

Hepato-nephrotoxicity in late juvenile of Oreochromis niloticus exposed to gibberellic acid: Ameliorative effect of Spirulina platensis.

The current work intended to inspect the hepato-nephrotoxicity of gibberellic acid (GA) in juvenile of Oreochromis niloticus as well as the possibility of restoration after dietary addition of different concentrations of Spirulina platensis (SP). Fishes were evenly assorted into five groups: Group I assigned as control, Group II fed on basal diet and exposed to 150 mg/L gibberellic acid (GA). The 3rd, 4th, and 5th groups exposed to150 mg/L gibberellic acid (GA) and previously fed for two months on SP supplemented diets at levels of 5, 20, and 100 g/kg, respectively.