Publications by authors named "Elfie De Jesus"
Article Synopsis
- Researchers created a system using immunocompromised mice to study how Zika virus (ZIKV) evolves during infection, focusing on its transmission and characteristics.
- They found that the way ZIKV is transmitted and the specific environments in different organs affect the virus's diversity and the types of defective genomes produced.
- The study also discovered ZIKV mutants that aligned with strains circulating in Asia and America, as well as unique mutations from the mouse model, enhancing our understanding of arbovirus evolution and the factors that influence it.
Arthropod-borne viruses represent a significant public health threat worldwide, yet there are few antiviral therapies or prophylaxes targeting these pathogens. In particular, the development of novel antivirals for high-risk populations such as pregnant women is essential to prevent devastating disease such as that which was experienced with the recent outbreak of Zika virus (ZIKV) in the Americas. One potential avenue to identify new and pregnancy-acceptable antiviral compounds is to repurpose well-known and widely used FDA-approved drugs.
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