The effects of rosiglitazone on the neonatal rat cardiomyocyte transcriptome: a temporal analysis.

The objective was to determine via high-throughput RNA sequencing the temporal effects of rosiglitazone (Avandia) on the neonatal rat ventricular myocyte transcriptome. Neonatal rat ventricular myocytes (NRVMs) were exposed to rosiglitazone . Meta analyses utilized temporal comparisons of 0.

Developmental and extracellular matrix-remodeling processes in rosiglitazone-exposed neonatal rat cardiomyocytes.

Objective: The objective of this study was to investigate the effects of rosiglitazone (Avandia(®)) on gene expression in neonatal rat ventricular myocytes.

Materials & Methods: Myocytes were exposed to rosiglitazone ex vivo. The two factors examined in the experiment were drug exposure (rosiglitazone and dimethyl sulfoxide vs dimethyl sulfoxide), and length of exposure to drug (½ h, 1 h, 2 h, 4 h, 6 h, 8 h, 12 h, 18 h, 24 h, 36 h and 48 h).