Publications by authors named "Eleonore Dijoux"
Background: Asthma is a chronic inflammatory airway disease characterized by a prevailing type 2 inflammation, airway hyperresponsiveness, and mucus hypersecretion and is driven by various factors among which oxidative molecules, called reactive oxygen species (ROS), play a major role. Superoxide dismutases (SODs) are enzymes that constitute the first line of defense against ROS. Melon SOD-gliadin, which is known as GliSODin®, is commonly used as a nutritional supplement that has proven antioxidant properties.
View Article and Find Full Text PDFArticle Synopsis
- Asthma affects over 300 million people globally, with 70% of cases linked to allergies, and is characterized by various endotypes and phenotypic diversities influenced by allergen exposure and the airway microbiome.
- The study compared different methods of sensitizing mice to house dust mites (HDM) via oral, nasal, and cutaneous routes, assessing lung function, immune response, and microbial composition.
- Results showed that nasal and cutaneous sensitization led to severe respiratory issues and inflammation, while oral sensitization resulted in milder symptoms, highlighting how the route of sensitization significantly affects asthma's severity and characteristics.
Article Synopsis
- - Allergic diseases are on the rise globally, possibly linked to increasing environmental chemical pollution like Bisphenol A (BPA), which affects the immune system and gut health.
- - A study using a mouse model tested the impact of BPA at a level similar to human exposure, revealing that it worsened food allergy symptoms and altered immune responses and gut microbiota.
- - The findings indicate that BPA exposure increases markers of food allergy and intestinal permeability, suggesting the European Food Safety Authority's tolerable daily intake for BPA may need to be reevaluated for its immunotoxic effects.
Background: Interleukin 15 (IL-15) is a growth and modulating factor for B, T lymphocytes and natural killer cells (NK). Its action on innate and adaptive immunity is modulated by its alpha chain receptor (IL-15Rα). The IL-15/sIL-15Rα complex (IL-15Cx) increases the bioavailability and activity of the cytokine in vivo.
View Article and Find Full Text PDFAsthma is often associated with a Th2-type immune response with well-known cellular and molecular actors such as eosinophils, Th2 lymphocytes and associated cytokines such as interleukin-5 or IL-4. Nevertheless, some of the asthmatic patients show clinical manifestations and characteristics that do not correspond to the current pattern of the pathophysiology of asthma. Thus, recently new cellular and molecular actors in the development of asthma have been demonstrated in animal models and in humans.
View Article and Find Full Text PDF